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Prostate cancer: New computer model enables researchers to predict course of disease

Date:
December 14, 2018
Source:
Charité - Universitätsmedizin Berlin
Summary:
How does a normal cell turn into a deadly cancer? Seeking an answer to this Question researchers examined the tumor genomes of nearly 300 prostate cancer patients. Their findings describe the ways in which changes in the prostate cells' genetic information pave the way for cancer development. Using a newly developed computer model, it is now possible to predict the course of the disease in individual patients.
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How does a normal cell turn into a deadly cancer? Seeking an answer to this question, and working alongside other international working groups, researchers from Charité -- Universitätsmedizin Berlin examined the tumor genomes of nearly 300 prostate cancer patients. Their findings describe the ways in which changes in the prostate cells' genetic information pave the way for cancer development. Using a newly-developed computer model, it is now possible to predict the course of the disease in individual patients. It is hoped this will enable clinicians to develop tailor-made treatments. On Monday, 10 December 2018, the results of this study were published in the latest issue of the journal Cancer Cell.

In Germany, prostate cancer is the most common malignancy in men, with close to 60,000 new cases diagnosed every year. These Tumors are usually slow-growing, meaning that not all patients require immediate treatment. Until recently, physicians had been unable to distinguish between benign and aggressive forms of the disease, particularly when dealing with tumors diagnosed at an early stage in the disease process.

Working alongside a number of other research groups from within Germany and abroad, Charité-based researchers helped to develop criteria that would make this type of classification possible. To do so, they studied the molecular profiles of close to 300 prostate tumors. They sequenced the information encoded within the cells' genetic material, recorded chemical changes to the genetic code, and measured the activity of specific genes within cancerous tissues. An analysis of their data has shed light upon the temporal order of mutational events involved in the development of prostate cancer. "We were able to identify tumor subtypes that progress at different rates and therefore require different types of treatment," says one of the study's lead authors, Prof. Dr. Thorsten Schlomm, Director of Charité's Department of Urology.

He adds: "We now know which of these mutations occur first, initiating the process of change from prostate cells to tumor cells, and which of them are more likely to follow later." The researchers then used these results to develop a computer-based model capable of predicting the likely course of the disease in individual patients. "When an individual patient's tumor shows a specific mutation, we are now able to predict which mutation is likely to follow, and how good the patient's prognosis is," explains Prof. Schlomm. "Our team is currently busy incorporating our computer model into the treatment process at Charité. This will enable clinicians to model a particular treatment's likelihood of success. As for the timescale involved, we expect it will take two to three years for this algorithm-based method to become clinical routine."

In an effort to improve the reliability of prognoses, the research consortium is planning to spend the next few years collating additional data on thousands of patients, which they will then use to further develop and enhance their computer model. They will achieve this by working with Berlin's newly established urology network (Hauptstadt-Urologie-Netzwerk), which brings together urology specialists from Charité and private practice. Their ultimate aim is to make it easier for physicians to decide on the most suitable treatments for individual patients.


Story Source:

Materials provided by Charité - Universitätsmedizin Berlin. Note: Content may be edited for style and length.


Journal Reference:

  1. Clarissa Gerhauser, Francesco Favero, Thomas Risch, Ronald Simon, Lars Feuerbach, Yassen Assenov, Doreen Heckmann, Nikos Sidiropoulos, Sebastian M. Waszak, Daniel Hübschmann, Alfonso Urbanucci, Etsehiwot G. Girma, Vladimir Kuryshev, Leszek J. Klimczak, Natalie Saini, Adrian M. Stütz, Dieter Weichenhan, Lisa-Marie Böttcher, Reka Toth, Josephine D. Hendriksen, Christina Koop, Pavlo Lutsik, Sören Matzk, Hans-Jörg Warnatz, Vyacheslav Amstislavskiy, Clarissa Feuerstein, Benjamin Raeder, Olga Bogatyrova, Eva-Maria Schmitz, Claudia Hube-Magg, Martina Kluth, Hartwig Huland, Markus Graefen, Chris Lawerenz, Gervaise H. Henry, Takafumi N. Yamaguchi, Alicia Malewska, Jan Meiners, Daniela Schilling, Eva Reisinger, Roland Eils, Matthias Schlesner, Douglas W. Strand, Robert G. Bristow, Paul C. Boutros, Christof von Kalle, Dmitry Gordenin, Holger Sültmann, Benedikt Brors, Guido Sauter, Christoph Plass, Marie-Laure Yaspo, Jan O. Korbel, Thorsten Schlomm, Joachim Weischenfeldt. Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories. Cancer Cell, 2018; 34 (6): 996 DOI: 10.1016/j.ccell.2018.10.016

Cite This Page:

Charité - Universitätsmedizin Berlin. "Prostate cancer: New computer model enables researchers to predict course of disease." ScienceDaily. ScienceDaily, 14 December 2018. <www.sciencedaily.com/releases/2018/12/181214093834.htm>.
Charité - Universitätsmedizin Berlin. (2018, December 14). Prostate cancer: New computer model enables researchers to predict course of disease. ScienceDaily. Retrieved March 27, 2024 from www.sciencedaily.com/releases/2018/12/181214093834.htm
Charité - Universitätsmedizin Berlin. "Prostate cancer: New computer model enables researchers to predict course of disease." ScienceDaily. www.sciencedaily.com/releases/2018/12/181214093834.htm (accessed March 27, 2024).

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